Dr. Ken Johnstone

Position:Senior Associate
Ken Johnstone

IP Qualifications

Registered Australian and New Zealand Patent Attorney
Registered Australian Trade Mark Attorney

Academic Qualifications

QualificationInstitutionYear of Completion
Doctor of Philosophy (PhD)University of New England2004
Bachelor of Science (Hons)University of Adelaide1999

Postdoctoral Research Experience

PositionOrganisation/InstitutionDate of Tenure
Postdoctoral Research FellowUniversity of Queensland2004-2005
Senior Postdoctoral Research FellowUniversity of Queensland2009-2011

Industry Experience

PositionOrganisation/InstitutionDate of Tenure
Lead Researcher (Head of Nanomaterials Division)Botswana Institute for Technology Research and Innovation2014-2016
Principal Research Scientist (Head of Food Chemistry Department)Botswana National Food Technology Research Centre2011-2014
Medicinal Chemist/Project ManagerProgen Pharmaceuticals2005-2009


The Institute of Patent and Trade Mark Attorneys of AustraliaMember

Selected Patent Cooperation (PCT) Specification

PCT Publication NumberTitle of Application
WO2018/102848Extruded Polyacrylonitrile Copolymer

Selected Publications - Patent

Scientific Publications
Ferro, Karoli, Lui, Handley, Johnstone et al. “Novel sulfated oligosaccharide derivatives”; AU 2008314505 B2, CA 2704201 C, EP 2205616 B1, JP 5509084 B, US 8,828,952, CN 101874035 B, IN 274501, IL 205143, RU2483074C2, KR101646960B1

Selected Publications - Scientific

Scientific Publications
Pandey, Johnstone et al. (2014) “Solution-processed pentathiophene dendrimer based photodetectors for digital cameras”, Sensors and Actuators B: Chemical, 196, 245-251.
Ferro, Liu, Johnstone et al. (2012) “Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis”, J. Med. Chem., 55(8): 3804-3813.
Van Vuuren, Johnstone et al. (2010) “Determining the absorption tolerance of single chromophore photodiodes for machine vision”, App. Phys. Lett., 96, 253303-253305, 2010
Said, Trybala, Andersson, Johnstone et al. (2010) “Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1”, Antiviral Research, 86(3), 286-295.
Ekblad, Adamiak, Bergström, Johnstone et al. (2010) “A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus”, Antiviral Research, 86(2), 196-203.
Johnstone et al. (2010) “Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth”, J. Med. Chem., 53(4), 1686–1699.
Dredge, Hammond, Davis, Li, Lui, Johnstone et al. (2010) “The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy”, Invest. New Drugs., 28(3), 276-283.
Lui, Johnstone et al. (2009) “An improved synthetic route to the potent angiogenesis inhibitor benzyl Manα(1→3)-Manα(1→3)-Manα (1→3)-Manα(1→2)-Man Hexadecasulfate”, Aust. J. Chem., 62(6) 546-552.
Mullen, Johnstone et al. (2009) “Crown-ether- and porphyrin-attached gel-phase resins in thermodynamically controlled rotaxane assembly”, Org. Biomol. Chem., 7(2) 293-303.
Merican, Johnstone et al. (2008) “Porphyrin-naphthodiimide interactions as a structural motif in foldamers and supramolecular assemblies”, Org. Biomol. Chem., 6(14) 2534-2543.
Mullen, Johnstone et al. (2008) “Monitoring the thermodynamically-controlled formation of diimide-based resin-attached rotaxanes by gel-phase HR MAS 1H NMR spectroscopy”, Org. Biomol. Chem., 6(2) 278-286.
Fairweather, Johnstone et al. (2008) “Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88”, Bioorg. Med. Chem., 16(2) 699-709.
Johnstone et al. (2006) “Gel-phase HR-MAS 1H NMR spectroscopy as a probe for solid-tethered diimide rotaxanes and catenanes”, New J. Chem., 30: 861-867.
Experience and Technical Background

Experienced in the following areas of patent practice:

  • Patent Drafting
  • Local and Foreign Patent Prosecution
  • Extensions of Patent Term (Pharmaceuticals)
  • Patentability Advice
  • Freedom to Operate Opinions
  • Oppositions

Primary patent practice areas by technology:

  • Organic Chemistry
  • Pharmaceuticals
  • Materials Chemistry

Research background:

General technical areas:

  • Organic Chemistry
  • Synthetic Chemistry
  • Pharmaceuticals
  • Materials Chemistry
  • Food Chemistry
  • Diagnostics

Honours research:

  • Porphyrin and pyrrole synthetic chemistry

PhD research:

  • Supramolecular synthetic chemistry (rotaxanes and catenanes).
  • Solution and solid-state host-guest chemistry.

Postdoctoral research:

    • Enzymatic synthesis of oligosaccharide-linked peptides for enhanced drug delivery.
    • Oral delivery of modified luteinizing hormone-releasing hormone derivatives.
    • Digital camera organic photodiodes.

Industry experience:

  • Medicinal chemistry: multiple growth factor binders and heparanase inhibitors.
  • Inventor on family of granted patents.
  • Drug discovery and development to phase 1 clinical.
  • Analysis of biochemistry, cell biology, preclinical toxicology and preclinical efficacy results.
  • Scale-up process development chemistry.
  • Optimisation of manufacturing process and analysis of process by-products for phase 3 clinical candidate.
  • Water purification research and product development.
  • Foot and mouth disease field diagnostic kit development.
  • Coal to chemicals research.
  • Mycotoxins food safety analysis, assay development and risk assessment.
  • Pesticides food safety analysis and risk management.
  • Traditional food composition analysis.
  • Sorghum vitamin A fortification product development.


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