Dr. Bernadette Hawkins

Position:Principal
Email:bernadette.hawkins@spruson.com
Bernadette Hawkins

IP Qualifications

Qualification
Registered Australian and New Zealand Patent Attorney
Registered Australian Trade Mark Attorney

Academic Qualifications

QualificationInstitutionYear of Completion
Master of Industrial PropertyUniversity of Technology Sydney, Australia2006
Doctor of Philosophy (PhD)Victorian College of Pharmacy, Monash University, Australia1995
Bachelor of Science (Hons)Monash University, Australia1987

Industry Experience

Position Organisation/InstitutionDate of Tenure
Examiner of PatentsIP Australia2004 - 2007
Research CoordinatorTherapeutics Research Group School of Medicine The University of Queensland2003
Postdoctoral Research AssociateDepartment of Biochemistry and Molecular Biology The University of Queensland1998 - 2002
AbstractorCurrent Biology Ltd1996 - 2000
Postdoctoral Research AssociateBiological NMR Centre, University of Leicester1995 - 1998
Research AssociateCentre for Drug Design and Development The University of Queensland1995
Research AssistantDepartment of Chemistry, Monash University1987 - 1988

Fellowships/Memberships/Affiliations

OrganisationLevel
The Institute of Patent and Trade Mark Attorneys of AustraliaFellow
Women in TechnologyMember

Selected Patent Cooperation Treaty (PCT) Specifications

PCT Publication NumberTitle of Application
WO/2017/205898Method of processing plant material
WO/2017/011863Neuroprotective agents derived from spider venom peptides
WO/2014/071438Modified polyphenols and modified polyphenol compositions
WO/2013/016776Composition and uses thereof
WO/2013/049894Surface stabiliser and uses thereof
WO/2011/072320Effervescent L-carnitine-based composition

Selected Publications - Scientific

Patent Publications
Hawkins BL, Cross KJ and Craik DJ, A 1H-NMR determination of the solution structure of the A-chain of insulin: comparison with the crystal structure and an examination of the role of solvent, Biochimica et Biophysica Acta, 1209, 177-182 (1994)
Hawkins B, Cross K and Craik D, Solution structure of the B-chain of insulin as determined by 1H NMR spectroscopy: Comparison with the crystal structure of the insulin hexamer and with the solution structure of the insulin monomer, Int. J. Peptide Protein Res., 46, 424-433 (1995)
Meutermans WDF, Alewood PF, Bourne GT, Hawkins BL and Smythe ML, Synthesis of α-aspartyl-containing cyclic peptides, Letters in Peptide Science, 4, 79-84 (1997)
Experience and Technical Background

Experienced in the following areas of patent practice:

  • Patent Drafting
  • Local and Foreign Patent Prosecution
  • Strategic Advice
  • Validity and Infringement
  • Patentability Advice
  • Extensions of Patent Term (Pharmaceuticals)

Primary patent practice areas by technology:

  • Pharmaceuticals
  • Organic Chemistry
  • Biochemistry
  • Immunology
  • Peptide Chemistry
  • Proteins
  • Synthetic Organic Chemistry
  • Protein-Protein Interactions
  • Protein Structure by NMR

Research/industry background:

A. General technical areas:

  • Organic Chemistry
  • Protein Biochemistry
  • Protein Structure by NMR
  • Protein-Protein Interactions

B. Honours research:

  • Organic Chemistry
  • Synthesis of proposed intermediates in a flash vacuum pyrolysis reaction

C. PhD research:

  • Drug design, Biochemistry and Computational Modelling.
  • Peptide purification using HPLC.
  • Nuclear magnetic resonance (NMR) studies.
  • Peptide structure calculations.
  • Design and synthesis of small organic molecules with the potential to bind to insulin, with the aim of gaining further control over the dissociation and hence in vivo activity of insulin. Interaction of these ligands with insulin monitored by nuclear magnetic resonance (NMR), and the solution structures of the individual chains of insulin were also determined.

D. Industry experience:

  • Protein expression (using E. coli) and purification (using ion exchange, gel filtration, immobilized metal affinity columns, FPLC).
  • RNA-protein interactions, including production and purification of RNA and proteins.
  • HPLC, mass spectrometry, NMR.
  • SDS-PAGE.
  • Protein-protein interactions using nuclear magnetic resonance, and surface plasmon resonance (BIAcore).
  • Preparing abstracts from recently reported protein structures for publication in Macromolecular Structures (an annual compilation of new atomic structures of biological macromolecules).
  • Rational drug design, based on current knowledge of anti-thrombotics.
  • Synthesis of small organic molecules, followed by characterization using standard methods such as mass spectrometry (MS), nuclear magnetic resonance (NMR), infrared spectroscopy (IR) and thin layer chromatography (TLC).
  • Testing of synthesized compounds for gastric toxicity, hepatic extraction and platelet aggregation.
  • Structural studies of cyclic pentapeptides using nuclear magnetic resonance and computational calculations using UNIX-based software.
  • Synthesis and analysis of potential anti-ulcer drugs.
  • Synthesis of pyrroles as part of a study into the preparation of porphyrins from pyrroles.
  • Selected Patent Cooperation Treaty (PCT) Specifications

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