IP Quaifications
| Qualification |
|---|
| Registered Australian and New Zealand Patent Attorney |
| Registered Australian Trade Mark Attorney |
Academic Qualifications
| Qualification | Institution | Year of completion |
|---|---|---|
| Master of Intellectual Property | University of Technology Sydney, Australia | 2023 |
| Doctor of Philosophy (Ph.D) | The University of Queensland, Australia | 2015 |
| Bachelor of Science Honours, Class I (Biochemistry and Molecular Biology) | The University of Queensland, Australia | 2010 |
| Bachelor of Science (Biochemistry and Biomedical Science) | The University of Queensland, Australia | 2009 |
Postdoctoral Experience
| Position | Organisation | Date of tenure |
|---|---|---|
| Postdoctoral Research Fellow | The University of Queensland Centre for Clinical Research | 2015-2022 |
Fellowships/Memberships/Affiliations
| Organisation | Level |
|---|---|
| Institute of Patent and Trade Mark Attorneys of Australia | Member |
| AusBiotech | Member |
Selected publications - Research
| Publications |
|---|
| Lavin MF, Yeo AJ. DNA damage rather than type I IFN signaling is the primary mediator of neural dysfunction in Aicardi-Goutières syndrome after RNASEH2 disruption. Neuron. 2021 Dec 15;109(24):3897-3900. doi: 10.1016/j.neuron.2021.11.019. |
| Yeo AJ, Subramanian GN, Chong KL, Gatei M, Parton RG, Coman D, Lavin MF. An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T). Mol Metab. 2021 Dec;54:101354. doi: 10.1016/j.molmet.2021.101354. |
| Yeo AJ, Chong KL, Gatei M, Zou D, Stewart R, Withey S, Wolvetang E, Parton RG, Brown AD, Kastan MB, Coman D, Lavin MF. Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia. iScience. 2020 Dec 23;24(1):101972. doi: 10.1016/j.isci.2020.101972. |
| Yeo AJ, Fantino E, Czovek D, Wainwright CE, Sly PD, Lavin MF. Loss of ATM in Airway Epithelial Cells Is Associated with Susceptibility to Oxidative Stress. Am J Respir Crit Care Med. 2017 Aug 1;196(3):391-393. doi: 10.1164/rccm.201611-2210LE. |
Experience and Technical Background
Experienced in the following areas of patent practice
- Local and foreign patent prosecution
- Patent drafting
- Patentability analysis
- Freedom-to-operate analysis
- IP strategy
Primary patent practice areas by technology
- Cellular and molecular biology
- Vaccines
- Genomics
- Proteomics
- Virology
- Immunology
- Biological assays
- Microbiology
- Diagnostics & Therapeutics
Research / Industry background
General technical areas:
- Genetics and genomics
- Biochemistry
- Molecular biology
- Microbiology
Honours research:
- Investigated the role of ADCK3 in autosomal recessive cerebellar ataxia type 2 (ARCA2)
PhD research:
- Characterised the first ataxia oculomotor apraxia type 2 (AOA2) mouse model and uncovered a role for senataxin in fertility and transcription regulation.
- Investigated the role of senataxin in resolving DNA:RNA hybrids (R-loops).
- Characterised neuronal iPSCs for AOA2 and generated a novel human disease model for identifying mechanism of pathology.
Postdoctoral experience:
- Developed an anaplerotic therapy to relieve metabolic stress and restore mitochondrial function in Ataxia-telangiectasia (A-T) patients, showing significant clinical improvement in a Phase 2A/B trial.
- Investigated how physiologically induced DNA double-strand breaks affect DNA repair in Purkinje cells of the cerebellum, particularly in the absence of ATM.
- Conducted a pilot study on the role of oxidative damage caused by microorganisms in lung disease observed in A-T.